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Depo-Provera, a form of hormonal contraception that contains medroxyprogesterone acetate, is known to influence lipid profiles in some individuals. When considering the impact of this medication on lipids, a notable undesirable effect is the decrease in high-density lipoprotein (HDL) cholesterol levels.

This is significant because HDL is often referred to as "good" cholesterol; it helps to remove other forms of cholesterol from the bloodstream and is associated with a lower risk of heart disease. A decrease in HDL can lead to an unfavorable balance in lipid levels and potentially contribute to cardiovascular risks.

Evidence in medical literature supports that many users of Depo-Provera experience a drop in HDL, making this a key concern for healthcare providers when discussing contraceptive options with patients, especially those at risk for cardiovascular disease. Although the medication can have other effects on lipid levels, the specific undesirable change in HDL is a crucial point of consideration for safe and effective prescribing.